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y=-4\left(x^{2}-10x+25\right)-3
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(x-5\right)^{2}.
y=-4x^{2}+40x-100-3
Use the distributive property to multiply -4 by x^{2}-10x+25.
y=-4x^{2}+40x-103
Subtract 3 from -100 to get -103.