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12x-3\left(5\times 4+3\right)=-2\left(12\times 6+1\right)
Multiply both sides of the equation by 12, the least common multiple of 4,6.
12x-3\left(20+3\right)=-2\left(12\times 6+1\right)
Multiply 5 and 4 to get 20.
12x-3\times 23=-2\left(12\times 6+1\right)
Add 20 and 3 to get 23.
12x-69=-2\left(12\times 6+1\right)
Multiply -3 and 23 to get -69.
12x-69=-2\left(72+1\right)
Multiply 12 and 6 to get 72.
12x-69=-2\times 73
Add 72 and 1 to get 73.
12x-69=-146
Multiply -2 and 73 to get -146.
12x=-146+69
Add 69 to both sides.
12x=-77
Add -146 and 69 to get -77.
x=\frac{-77}{12}
Divide both sides by 12.
x=-\frac{77}{12}
Fraction \frac{-77}{12} can be rewritten as -\frac{77}{12} by extracting the negative sign.