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4x-\left(-2\left(5\times 2+1\right)\right)=-\left(8\times 4+1\right)
Multiply both sides of the equation by 4, the least common multiple of 2,4.
4x-\left(-2\left(10+1\right)\right)=-\left(8\times 4+1\right)
Multiply 5 and 2 to get 10.
4x-\left(-2\times 11\right)=-\left(8\times 4+1\right)
Add 10 and 1 to get 11.
4x-\left(-22\right)=-\left(8\times 4+1\right)
Multiply -2 and 11 to get -22.
4x+22=-\left(8\times 4+1\right)
The opposite of -22 is 22.
4x+22=-\left(32+1\right)
Multiply 8 and 4 to get 32.
4x+22=-33
Add 32 and 1 to get 33.
4x=-33-22
Subtract 22 from both sides.
4x=-55
Subtract 22 from -33 to get -55.
x=\frac{-55}{4}
Divide both sides by 4.
x=-\frac{55}{4}
Fraction \frac{-55}{4} can be rewritten as -\frac{55}{4} by extracting the negative sign.