Factor
\left(x+1\right)\left(x+4\right)\left(x^{2}-x+1\right)\left(x^{2}-4x+16\right)
Evaluate
x^{6}+65x^{3}+64
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x^{6}+65x^{3}+64
Multiply and combine like terms.
\left(x^{3}+64\right)\left(x^{3}+1\right)
Find one factor of the form x^{k}+m, where x^{k} divides the monomial with the highest power x^{6} and m divides the constant factor 64. One such factor is x^{3}+64. Factor the polynomial by dividing it by this factor.
\left(x+4\right)\left(x^{2}-4x+16\right)
Consider x^{3}+64. Rewrite x^{3}+64 as x^{3}+4^{3}. The sum of cubes can be factored using the rule: a^{3}+b^{3}=\left(a+b\right)\left(a^{2}-ab+b^{2}\right).
\left(x+1\right)\left(x^{2}-x+1\right)
Consider x^{3}+1. Rewrite x^{3}+1 as x^{3}+1^{3}. The sum of cubes can be factored using the rule: a^{3}+b^{3}=\left(a+b\right)\left(a^{2}-ab+b^{2}\right).
\left(x^{2}-x+1\right)\left(x+1\right)\left(x+4\right)\left(x^{2}-4x+16\right)
Rewrite the complete factored expression. The following polynomials are not factored since they do not have any rational roots: x^{2}-x+1,x^{2}-4x+16.
x^{6}+65x^{3}+64
Combine 64x^{3} and x^{3} to get 65x^{3}.
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