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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(x^{6}\left(-3\right))
To multiply powers of the same base, add their exponents. Add 4 and 2 to get 6.
6\left(-3\right)x^{6-1}
The derivative of ax^{n} is nax^{n-1}.
-18x^{6-1}
Multiply 6 times -3.
-18x^{5}
Subtract 1 from 6.
x^{6}\left(-3\right)
To multiply powers of the same base, add their exponents. Add 4 and 2 to get 6.