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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(-43x^{2}-7x-100)
Combine x^{2} and -44x^{2} to get -43x^{2}.
2\left(-43\right)x^{2-1}-7x^{1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-86x^{2-1}-7x^{1-1}
Multiply 2 times -43.
-86x^{1}-7x^{1-1}
Subtract 1 from 2.
-86x^{1}-7x^{0}
Subtract 1 from 1.
-86x-7x^{0}
For any term t, t^{1}=t.
-86x-7
For any term t except 0, t^{0}=1.
-43x^{2}-7x-100
Combine x^{2} and -44x^{2} to get -43x^{2}.