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Differentiate w.r.t. x
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x^{-2}y^{3}\left(\left(-x^{5}\right)y^{3}\right)^{4}
To multiply powers of the same base, add their exponents. Add 0 and 3 to get 3.
x^{-2}y^{3}\left(-x^{5}\right)^{4}\left(y^{3}\right)^{4}
Expand \left(\left(-x^{5}\right)y^{3}\right)^{4}.
x^{-2}y^{3}\left(-x^{5}\right)^{4}y^{12}
To raise a power to another power, multiply the exponents. Multiply 3 and 4 to get 12.
x^{-2}y^{15}\left(-x^{5}\right)^{4}
To multiply powers of the same base, add their exponents. Add 3 and 12 to get 15.
x^{-2}y^{15}\left(-1\right)^{4}\left(x^{5}\right)^{4}
Expand \left(-x^{5}\right)^{4}.
x^{-2}y^{15}\left(-1\right)^{4}x^{20}
To raise a power to another power, multiply the exponents. Multiply 5 and 4 to get 20.
x^{-2}y^{15}\times 1x^{20}
Calculate -1 to the power of 4 and get 1.
x^{18}y^{15}\times 1
To multiply powers of the same base, add their exponents. Add -2 and 20 to get 18.
x^{18}y^{15}
For any term t, t\times 1=t and 1t=t.