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Differentiate w.r.t. x
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\frac{1}{2}x^{\frac{1}{2}-1}+\frac{1}{4}\left(-5\right)x^{\frac{1}{4}-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{1}{2}x^{-\frac{1}{2}}+\frac{1}{4}\left(-5\right)x^{\frac{1}{4}-1}
Subtract 1 from \frac{1}{2}.
\frac{1}{2}x^{-\frac{1}{2}}-\frac{5}{4}x^{\frac{1}{4}-1}
Multiply \frac{1}{4} times -5.
\frac{1}{2}x^{-\frac{1}{2}}-\frac{5}{4}x^{-\frac{3}{4}}
Subtract 1 from \frac{1}{4}.