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Differentiate w.r.t. x
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\left(2x^{5}\right)^{1}\times \frac{1}{x^{8}}
Use the rules of exponents to simplify the expression.
2^{1}\left(x^{5}\right)^{1}\times \frac{1}{1}\times \frac{1}{x^{8}}
To raise the product of two or more numbers to a power, raise each number to the power and take their product.
2^{1}\times \frac{1}{1}\left(x^{5}\right)^{1}\times \frac{1}{x^{8}}
Use the Commutative Property of Multiplication.
2^{1}\times \frac{1}{1}x^{5}x^{8\left(-1\right)}
To raise a power to another power, multiply the exponents.
2^{1}\times \frac{1}{1}x^{5}x^{-8}
Multiply 8 times -1.
2^{1}\times \frac{1}{1}x^{5-8}
To multiply powers of the same base, add their exponents.
2^{1}\times \frac{1}{1}x^{-3}
Add the exponents 5 and -8.
2\times \frac{1}{1}x^{-3}
Raise 2 to the power 1.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{2}{1}x^{5-8})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(2x^{-3})
Do the arithmetic.
-3\times 2x^{-3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-6x^{-4}
Do the arithmetic.