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Differentiate w.r.t. x_0
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2\times 2x_{0}^{2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
4x_{0}^{2-1}
Multiply 2 times 2.
4x_{0}^{1}
Subtract 1 from 2.
4x_{0}
For any term t, t^{1}=t.