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Differentiate w.r.t. x
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5\times 9x^{5-1}+3\times 8x^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
45x^{5-1}+3\times 8x^{3-1}
Multiply 5 times 9.
45x^{4}+3\times 8x^{3-1}
Subtract 1 from 5.
45x^{4}+24x^{3-1}
Multiply 3 times 8.
45x^{4}+24x^{2}
Subtract 1 from 3.