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Differentiate w.r.t. x
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4\times 4x^{4-1}+2\left(-3\right)x^{2-1}+2x^{1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
16x^{4-1}+2\left(-3\right)x^{2-1}+2x^{1-1}
Multiply 4 times 4.
16x^{3}+2\left(-3\right)x^{2-1}+2x^{1-1}
Subtract 1 from 4.
16x^{3}-6x^{2-1}+2x^{1-1}
Multiply 2 times -3.
16x^{3}-6x^{1}+2x^{1-1}
Subtract 1 from 2.
16x^{3}-6x^{1}+2x^{0}
Subtract 1 from 1.
16x^{3}-6x+2x^{0}
For any term t, t^{1}=t.
16x^{3}-6x+2\times 1
For any term t except 0, t^{0}=1.
16x^{3}-6x+2
For any term t, t\times 1=t and 1t=t.