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2\times 16-4\left(-4\right)+1
Calculate -4 to the power of 2 and get 16.
32-4\left(-4\right)+1
Multiply 2 and 16 to get 32.
32-\left(-16\right)+1
Multiply 4 and -4 to get -16.
32+16+1
The opposite of -16 is 16.
48+1
Add 32 and 16 to get 48.
49
Add 48 and 1 to get 49.