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Differentiate w.r.t. x
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2\left(-6\right)x^{2-1}+3\left(-1\right)x^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-12x^{2-1}+3\left(-1\right)x^{3-1}
Multiply 2 times -6.
-12x^{1}+3\left(-1\right)x^{3-1}
Subtract 1 from 2.
-12x^{1}-3x^{3-1}
Multiply 3 times -1.
-12x^{1}-3x^{2}
Subtract 1 from 3.
-12x-3x^{2}
For any term t, t^{1}=t.