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-4\left(-64\left(x^{2}\right)^{3}+768\left(x^{2}\right)^{2}-3072x^{2}+4096\right)+5
Use binomial theorem \left(a+b\right)^{3}=a^{3}+3a^{2}b+3ab^{2}+b^{3} to expand \left(-4x^{2}+16\right)^{3}.
-4\left(-64x^{6}+768\left(x^{2}\right)^{2}-3072x^{2}+4096\right)+5
To raise a power to another power, multiply the exponents. Multiply 2 and 3 to get 6.
-4\left(-64x^{6}+768x^{4}-3072x^{2}+4096\right)+5
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
256x^{6}-3072x^{4}+12288x^{2}-16384+5
Use the distributive property to multiply -4 by -64x^{6}+768x^{4}-3072x^{2}+4096.
256x^{6}-3072x^{4}+12288x^{2}-16379
Add -16384 and 5 to get -16379.
-4\left(-64\left(x^{2}\right)^{3}+768\left(x^{2}\right)^{2}-3072x^{2}+4096\right)+5
Use binomial theorem \left(a+b\right)^{3}=a^{3}+3a^{2}b+3ab^{2}+b^{3} to expand \left(-4x^{2}+16\right)^{3}.
-4\left(-64x^{6}+768\left(x^{2}\right)^{2}-3072x^{2}+4096\right)+5
To raise a power to another power, multiply the exponents. Multiply 2 and 3 to get 6.
-4\left(-64x^{6}+768x^{4}-3072x^{2}+4096\right)+5
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
256x^{6}-3072x^{4}+12288x^{2}-16384+5
Use the distributive property to multiply -4 by -64x^{6}+768x^{4}-3072x^{2}+4096.
256x^{6}-3072x^{4}+12288x^{2}-16379
Add -16384 and 5 to get -16379.