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Differentiate w.r.t. x
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4\left(-3\right)x^{4-1}+3\times 5x^{3-1}-x^{1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-12x^{4-1}+3\times 5x^{3-1}-x^{1-1}
Multiply 4 times -3.
-12x^{3}+3\times 5x^{3-1}-x^{1-1}
Subtract 1 from 4.
-12x^{3}+15x^{3-1}-x^{1-1}
Multiply 3 times 5.
-12x^{3}+15x^{2}-x^{1-1}
Subtract 1 from 3.
-12x^{3}+15x^{2}-x^{0}
Subtract 1 from 1.
-12x^{3}+15x^{2}-1
For any term t except 0, t^{0}=1.