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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(-x^{4})
To raise a power to another power, multiply the exponents. Multiply \frac{2}{3} and 6 to get 4.
4\left(-1\right)x^{4-1}
The derivative of ax^{n} is nax^{n-1}.
-4x^{4-1}
Multiply 4 times -1.
-4x^{3}
Subtract 1 from 4.