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\left(x^{3}+12x^{2}+48x+64\right)\left(x^{2}+4\right)
Use binomial theorem \left(a+b\right)^{3}=a^{3}+3a^{2}b+3ab^{2}+b^{3} to expand \left(x+4\right)^{3}.
x^{5}+52x^{3}+12x^{4}+112x^{2}+192x+256
Use the distributive property to multiply x^{3}+12x^{2}+48x+64 by x^{2}+4 and combine like terms.
\left(x^{3}+12x^{2}+48x+64\right)\left(x^{2}+4\right)
Use binomial theorem \left(a+b\right)^{3}=a^{3}+3a^{2}b+3ab^{2}+b^{3} to expand \left(x+4\right)^{3}.
x^{5}+52x^{3}+12x^{4}+112x^{2}+192x+256
Use the distributive property to multiply x^{3}+12x^{2}+48x+64 by x^{2}+4 and combine like terms.