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\left(ab^{2}c^{3}-12\right)\left(ab^{2}c^{3}+12\right)
Rewrite a^{2}b^{4}c^{6}-144 as \left(ab^{2}c^{3}\right)^{2}-12^{2}. The difference of squares can be factored using the rule: p^{2}-q^{2}=\left(p-q\right)\left(p+q\right).