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Differentiate w.r.t. a
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\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{1}a^{-16-\left(-6\right)})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(a^{-10})
Do the arithmetic.
-10a^{-10-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-10a^{-11}
Do the arithmetic.
\frac{1}{a^{10}}
Rewrite a^{-6} as a^{-16}a^{10}. Cancel out a^{-16} in both numerator and denominator.