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Differentiate w.r.t. x
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4\left(-8\right)x^{4-1}+6\times 36x^{6-1}+3\left(-54\right)x^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-32x^{4-1}+6\times 36x^{6-1}+3\left(-54\right)x^{3-1}
Multiply 4 times -8.
-32x^{3}+6\times 36x^{6-1}+3\left(-54\right)x^{3-1}
Subtract 1 from 4.
-32x^{3}+216x^{6-1}+3\left(-54\right)x^{3-1}
Multiply 6 times 36.
-32x^{3}+216x^{5}+3\left(-54\right)x^{3-1}
Subtract 1 from 6.
-32x^{3}+216x^{5}-162x^{3-1}
Multiply 6 times 36.
-32x^{3}+216x^{5}-162x^{2}
Subtract 1 from 3.