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Differentiate w.r.t. x
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3\times 4x^{3-1}+2\left(-3\right)x^{2-1}-18x^{1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
12x^{3-1}+2\left(-3\right)x^{2-1}-18x^{1-1}
Multiply 3 times 4.
12x^{2}+2\left(-3\right)x^{2-1}-18x^{1-1}
Subtract 1 from 3.
12x^{2}-6x^{2-1}-18x^{1-1}
Multiply 2 times -3.
12x^{2}-6x^{1}-18x^{1-1}
Subtract 1 from 2.
12x^{2}-6x^{1}-18x^{0}
Subtract 1 from 1.
12x^{2}-6x-18x^{0}
For any term t, t^{1}=t.
12x^{2}-6x-18
For any term t except 0, t^{0}=1.