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9x^{2}-4\left(y^{2}+4yx+4x^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(y+2x\right)^{2}.
9x^{2}-4y^{2}-16yx-16x^{2}
Use the distributive property to multiply -4 by y^{2}+4yx+4x^{2}.
-7x^{2}-4y^{2}-16yx
Combine 9x^{2} and -16x^{2} to get -7x^{2}.
9x^{2}-4\left(y^{2}+4yx+4x^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(y+2x\right)^{2}.
9x^{2}-4y^{2}-16yx-16x^{2}
Use the distributive property to multiply -4 by y^{2}+4yx+4x^{2}.
-7x^{2}-4y^{2}-16yx
Combine 9x^{2} and -16x^{2} to get -7x^{2}.