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8000e^{-100000\times \frac{290}{273\times 8.317}}
Multiply 29 and 10 to get 290.
8000e^{-100000\times \frac{290}{2270.541}}
Multiply 273 and 8.317 to get 2270.541.
8000e^{-100000\times \frac{290000}{2270541}}
Expand \frac{290}{2270.541} by multiplying both numerator and the denominator by 1000.
8000e^{-\frac{29000000000}{2270541}}
Multiply -100000 and \frac{290000}{2270541} to get -\frac{29000000000}{2270541}.