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8\left(x^{2}-2xy+y^{2}\right)-50\left(2x+y\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(x-y\right)^{2}.
8x^{2}-16xy+8y^{2}-50\left(2x+y\right)^{2}
Use the distributive property to multiply 8 by x^{2}-2xy+y^{2}.
8x^{2}-16xy+8y^{2}-50\left(4x^{2}+4xy+y^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(2x+y\right)^{2}.
8x^{2}-16xy+8y^{2}-200x^{2}-200xy-50y^{2}
Use the distributive property to multiply -50 by 4x^{2}+4xy+y^{2}.
-192x^{2}-16xy+8y^{2}-200xy-50y^{2}
Combine 8x^{2} and -200x^{2} to get -192x^{2}.
-192x^{2}-216xy+8y^{2}-50y^{2}
Combine -16xy and -200xy to get -216xy.
-192x^{2}-216xy-42y^{2}
Combine 8y^{2} and -50y^{2} to get -42y^{2}.
8\left(x^{2}-2xy+y^{2}\right)-50\left(2x+y\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(x-y\right)^{2}.
8x^{2}-16xy+8y^{2}-50\left(2x+y\right)^{2}
Use the distributive property to multiply 8 by x^{2}-2xy+y^{2}.
8x^{2}-16xy+8y^{2}-50\left(4x^{2}+4xy+y^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(2x+y\right)^{2}.
8x^{2}-16xy+8y^{2}-200x^{2}-200xy-50y^{2}
Use the distributive property to multiply -50 by 4x^{2}+4xy+y^{2}.
-192x^{2}-16xy+8y^{2}-200xy-50y^{2}
Combine 8x^{2} and -200x^{2} to get -192x^{2}.
-192x^{2}-216xy+8y^{2}-50y^{2}
Combine -16xy and -200xy to get -216xy.
-192x^{2}-216xy-42y^{2}
Combine 8y^{2} and -50y^{2} to get -42y^{2}.