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49\left(2-3+6\right)-64^{18}\left(6+\left(3+2\left(4+2\right)^{2}-1\right)\left(-1\right)\right)
Calculate 7 to the power of 2 and get 49.
49\left(-1+6\right)-64^{18}\left(6+\left(3+2\left(4+2\right)^{2}-1\right)\left(-1\right)\right)
Subtract 3 from 2 to get -1.
49\times 5-64^{18}\left(6+\left(3+2\left(4+2\right)^{2}-1\right)\left(-1\right)\right)
Add -1 and 6 to get 5.
245-64^{18}\left(6+\left(3+2\left(4+2\right)^{2}-1\right)\left(-1\right)\right)
Multiply 49 and 5 to get 245.
245-324518553658426726783156020576256\left(6+\left(3+2\left(4+2\right)^{2}-1\right)\left(-1\right)\right)
Calculate 64 to the power of 18 and get 324518553658426726783156020576256.
245-324518553658426726783156020576256\left(6+\left(3+2\times 6^{2}-1\right)\left(-1\right)\right)
Add 4 and 2 to get 6.
245-324518553658426726783156020576256\left(6+\left(3+2\times 36-1\right)\left(-1\right)\right)
Calculate 6 to the power of 2 and get 36.
245-324518553658426726783156020576256\left(6+\left(3+72-1\right)\left(-1\right)\right)
Multiply 2 and 36 to get 72.
245-324518553658426726783156020576256\left(6+\left(75-1\right)\left(-1\right)\right)
Add 3 and 72 to get 75.
245-324518553658426726783156020576256\left(6+74\left(-1\right)\right)
Subtract 1 from 75 to get 74.
245-324518553658426726783156020576256\left(6-74\right)
Multiply 74 and -1 to get -74.
245-324518553658426726783156020576256\left(-68\right)
Subtract 74 from 6 to get -68.
245-\left(-22067261648773017421254609399185408\right)
Multiply 324518553658426726783156020576256 and -68 to get -22067261648773017421254609399185408.
245+22067261648773017421254609399185408
The opposite of -22067261648773017421254609399185408 is 22067261648773017421254609399185408.
22067261648773017421254609399185653
Add 245 and 22067261648773017421254609399185408 to get 22067261648773017421254609399185653.