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6.43\times \frac{1}{100000}-0.25\times 10^{-3}
Calculate 10 to the power of -5 and get \frac{1}{100000}.
\frac{643}{10000000}-0.25\times 10^{-3}
Multiply 6.43 and \frac{1}{100000} to get \frac{643}{10000000}.
\frac{643}{10000000}-0.25\times \frac{1}{1000}
Calculate 10 to the power of -3 and get \frac{1}{1000}.
\frac{643}{10000000}-\frac{1}{4000}
Multiply 0.25 and \frac{1}{1000} to get \frac{1}{4000}.
-\frac{1857}{10000000}
Subtract \frac{1}{4000} from \frac{643}{10000000} to get -\frac{1857}{10000000}.