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Differentiate w.r.t. s
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\frac{\mathrm{d}}{\mathrm{d}s}(-162s^{4})
Combine 54s^{4} and -216s^{4} to get -162s^{4}.
4\left(-162\right)s^{4-1}
The derivative of ax^{n} is nax^{n-1}.
-648s^{4-1}
Multiply 4 times -162.
-648s^{3}
Subtract 1 from 4.
-162s^{4}
Combine 54s^{4} and -216s^{4} to get -162s^{4}.