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\left(10x+25y\right)\left(2x-5y\right)+\left(2x+y\right)\left(-2x-y\right)
Use the distributive property to multiply 5 by 2x+5y.
20x^{2}-50xy+50yx-125y^{2}+\left(2x+y\right)\left(-2x-y\right)
Apply the distributive property by multiplying each term of 10x+25y by each term of 2x-5y.
20x^{2}-125y^{2}+\left(2x+y\right)\left(-2x-y\right)
Combine -50xy and 50yx to get 0.
20x^{2}-125y^{2}-4x^{2}-2xy-2yx-y^{2}
Apply the distributive property by multiplying each term of 2x+y by each term of -2x-y.
20x^{2}-125y^{2}-4x^{2}-4xy-y^{2}
Combine -2xy and -2yx to get -4xy.
16x^{2}-125y^{2}-4xy-y^{2}
Combine 20x^{2} and -4x^{2} to get 16x^{2}.
16x^{2}-126y^{2}-4xy
Combine -125y^{2} and -y^{2} to get -126y^{2}.
\left(10x+25y\right)\left(2x-5y\right)+\left(2x+y\right)\left(-2x-y\right)
Use the distributive property to multiply 5 by 2x+5y.
20x^{2}-50xy+50yx-125y^{2}+\left(2x+y\right)\left(-2x-y\right)
Apply the distributive property by multiplying each term of 10x+25y by each term of 2x-5y.
20x^{2}-125y^{2}+\left(2x+y\right)\left(-2x-y\right)
Combine -50xy and 50yx to get 0.
20x^{2}-125y^{2}-4x^{2}-2xy-2yx-y^{2}
Apply the distributive property by multiplying each term of 2x+y by each term of -2x-y.
20x^{2}-125y^{2}-4x^{2}-4xy-y^{2}
Combine -2xy and -2yx to get -4xy.
16x^{2}-125y^{2}-4xy-y^{2}
Combine 20x^{2} and -4x^{2} to get 16x^{2}.
16x^{2}-126y^{2}-4xy
Combine -125y^{2} and -y^{2} to get -126y^{2}.