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Differentiate w.r.t. x
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-\frac{5}{4}x^{-1-1}
The derivative of ax^{n} is nax^{n-1}.
-\frac{5}{4}x^{-2}
Subtract 1 from -1.
\frac{5}{4x}
Express \frac{\frac{5}{4}}{x} as a single fraction.