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45-\left(-\left(-3\right)+4^{3}\right)
Fraction \frac{3}{-1} can be rewritten as -3 by extracting the negative sign.
45-\left(3+4^{3}\right)
The opposite of -3 is 3.
45-\left(3+64\right)
Calculate 4 to the power of 3 and get 64.
45-67
Add 3 and 64 to get 67.
-22
Subtract 67 from 45 to get -22.