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400-5\left(32-2\left(18-2\left(16-\left(-2\right)^{4}\right)\right)\right)+\left(-5\right)^{6}
To multiply powers of the same base, add their exponents. Add 4 and 2 to get 6.
400-5\left(32-2\left(18-2\left(16-16\right)\right)\right)+\left(-5\right)^{6}
Calculate -2 to the power of 4 and get 16.
400-5\left(32-2\left(18-2\times 0\right)\right)+\left(-5\right)^{6}
Subtract 16 from 16 to get 0.
400-5\left(32-2\left(18-0\right)\right)+\left(-5\right)^{6}
Multiply 2 and 0 to get 0.
400-5\left(32-2\times 18\right)+\left(-5\right)^{6}
Subtract 0 from 18 to get 18.
400-5\left(32-36\right)+\left(-5\right)^{6}
Multiply -2 and 18 to get -36.
400-5\left(-4\right)+\left(-5\right)^{6}
Subtract 36 from 32 to get -4.
400-\left(-20\right)+\left(-5\right)^{6}
Multiply 5 and -4 to get -20.
400+20+\left(-5\right)^{6}
The opposite of -20 is 20.
420+\left(-5\right)^{6}
Add 400 and 20 to get 420.
420+15625
Calculate -5 to the power of 6 and get 15625.
16045
Add 420 and 15625 to get 16045.