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Differentiate w.r.t. x
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4\times 4x^{4-1}+2\times 2x^{2-1}+7\left(-3\right)x^{7-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
16x^{4-1}+2\times 2x^{2-1}+7\left(-3\right)x^{7-1}
Multiply 4 times 4.
16x^{3}+2\times 2x^{2-1}+7\left(-3\right)x^{7-1}
Subtract 1 from 4.
16x^{3}+4x^{2-1}+7\left(-3\right)x^{7-1}
Multiply 2 times 2.
16x^{3}+4x^{1}+7\left(-3\right)x^{7-1}
Subtract 1 from 2.
16x^{3}+4x^{1}-21x^{7-1}
Multiply 2 times 2.
16x^{3}+4x^{1}-21x^{6}
Subtract 1 from 7.
16x^{3}+4x-21x^{6}
For any term t, t^{1}=t.