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x^{2}\left(4x-1\right)-16\left(4x-1\right)
Do the grouping 4x^{3}-x^{2}-64x+16=\left(4x^{3}-x^{2}\right)+\left(-64x+16\right), and factor out x^{2} in the first and -16 in the second group.
\left(4x-1\right)\left(x^{2}-16\right)
Factor out common term 4x-1 by using distributive property.
\left(x-4\right)\left(x+4\right)
Consider x^{2}-16. Rewrite x^{2}-16 as x^{2}-4^{2}. The difference of squares can be factored using the rule: a^{2}-b^{2}=\left(a-b\right)\left(a+b\right).
\left(x-4\right)\left(4x-1\right)\left(x+4\right)
Rewrite the complete factored expression.