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4\left(x^{2}-2xy+y^{2}\right)-25\left(x+y\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(x-y\right)^{2}.
4x^{2}-8xy+4y^{2}-25\left(x+y\right)^{2}
Use the distributive property to multiply 4 by x^{2}-2xy+y^{2}.
4x^{2}-8xy+4y^{2}-25\left(x^{2}+2xy+y^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(x+y\right)^{2}.
4x^{2}-8xy+4y^{2}-25x^{2}-50xy-25y^{2}
Use the distributive property to multiply -25 by x^{2}+2xy+y^{2}.
-21x^{2}-8xy+4y^{2}-50xy-25y^{2}
Combine 4x^{2} and -25x^{2} to get -21x^{2}.
-21x^{2}-58xy+4y^{2}-25y^{2}
Combine -8xy and -50xy to get -58xy.
-21x^{2}-58xy-21y^{2}
Combine 4y^{2} and -25y^{2} to get -21y^{2}.
4\left(x^{2}-2xy+y^{2}\right)-25\left(x+y\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(x-y\right)^{2}.
4x^{2}-8xy+4y^{2}-25\left(x+y\right)^{2}
Use the distributive property to multiply 4 by x^{2}-2xy+y^{2}.
4x^{2}-8xy+4y^{2}-25\left(x^{2}+2xy+y^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(x+y\right)^{2}.
4x^{2}-8xy+4y^{2}-25x^{2}-50xy-25y^{2}
Use the distributive property to multiply -25 by x^{2}+2xy+y^{2}.
-21x^{2}-8xy+4y^{2}-50xy-25y^{2}
Combine 4x^{2} and -25x^{2} to get -21x^{2}.
-21x^{2}-58xy+4y^{2}-25y^{2}
Combine -8xy and -50xy to get -58xy.
-21x^{2}-58xy-21y^{2}
Combine 4y^{2} and -25y^{2} to get -21y^{2}.