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4\left(p^{2}+2pq+q^{2}\right)-\left(2p+q\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(p+q\right)^{2}.
4p^{2}+8pq+4q^{2}-\left(2p+q\right)^{2}
Use the distributive property to multiply 4 by p^{2}+2pq+q^{2}.
4p^{2}+8pq+4q^{2}-\left(4p^{2}+4pq+q^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(2p+q\right)^{2}.
4p^{2}+8pq+4q^{2}-4p^{2}-4pq-q^{2}
To find the opposite of 4p^{2}+4pq+q^{2}, find the opposite of each term.
8pq+4q^{2}-4pq-q^{2}
Combine 4p^{2} and -4p^{2} to get 0.
4pq+4q^{2}-q^{2}
Combine 8pq and -4pq to get 4pq.
4pq+3q^{2}
Combine 4q^{2} and -q^{2} to get 3q^{2}.
4\left(p^{2}+2pq+q^{2}\right)-\left(2p+q\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(p+q\right)^{2}.
4p^{2}+8pq+4q^{2}-\left(2p+q\right)^{2}
Use the distributive property to multiply 4 by p^{2}+2pq+q^{2}.
4p^{2}+8pq+4q^{2}-\left(4p^{2}+4pq+q^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(2p+q\right)^{2}.
4p^{2}+8pq+4q^{2}-4p^{2}-4pq-q^{2}
To find the opposite of 4p^{2}+4pq+q^{2}, find the opposite of each term.
8pq+4q^{2}-4pq-q^{2}
Combine 4p^{2} and -4p^{2} to get 0.
4pq+4q^{2}-q^{2}
Combine 8pq and -4pq to get 4pq.
4pq+3q^{2}
Combine 4q^{2} and -q^{2} to get 3q^{2}.