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4\left(4p^{2}+12pq+9q^{2}\right)-\left(3p-q\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(2p+3q\right)^{2}.
16p^{2}+48pq+36q^{2}-\left(3p-q\right)^{2}
Use the distributive property to multiply 4 by 4p^{2}+12pq+9q^{2}.
16p^{2}+48pq+36q^{2}-\left(9p^{2}-6pq+q^{2}\right)
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(3p-q\right)^{2}.
16p^{2}+48pq+36q^{2}-9p^{2}+6pq-q^{2}
To find the opposite of 9p^{2}-6pq+q^{2}, find the opposite of each term.
7p^{2}+48pq+36q^{2}+6pq-q^{2}
Combine 16p^{2} and -9p^{2} to get 7p^{2}.
7p^{2}+54pq+36q^{2}-q^{2}
Combine 48pq and 6pq to get 54pq.
7p^{2}+54pq+35q^{2}
Combine 36q^{2} and -q^{2} to get 35q^{2}.
4\left(4p^{2}+12pq+9q^{2}\right)-\left(3p-q\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(2p+3q\right)^{2}.
16p^{2}+48pq+36q^{2}-\left(3p-q\right)^{2}
Use the distributive property to multiply 4 by 4p^{2}+12pq+9q^{2}.
16p^{2}+48pq+36q^{2}-\left(9p^{2}-6pq+q^{2}\right)
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(3p-q\right)^{2}.
16p^{2}+48pq+36q^{2}-9p^{2}+6pq-q^{2}
To find the opposite of 9p^{2}-6pq+q^{2}, find the opposite of each term.
7p^{2}+48pq+36q^{2}+6pq-q^{2}
Combine 16p^{2} and -9p^{2} to get 7p^{2}.
7p^{2}+54pq+36q^{2}-q^{2}
Combine 48pq and 6pq to get 54pq.
7p^{2}+54pq+35q^{2}
Combine 36q^{2} and -q^{2} to get 35q^{2}.