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Differentiate w.r.t. x
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\frac{\left(4x^{3}+3x^{2}-16x\right)\left(x+2\right)}{x+2}-\frac{12}{x+2}
To add or subtract expressions, expand them to make their denominators the same. Multiply 4x^{3}+3x^{2}-16x times \frac{x+2}{x+2}.
\frac{\left(4x^{3}+3x^{2}-16x\right)\left(x+2\right)-12}{x+2}
Since \frac{\left(4x^{3}+3x^{2}-16x\right)\left(x+2\right)}{x+2} and \frac{12}{x+2} have the same denominator, subtract them by subtracting their numerators.
\frac{4x^{4}+8x^{3}+3x^{3}+6x^{2}-16x^{2}-32x-12}{x+2}
Do the multiplications in \left(4x^{3}+3x^{2}-16x\right)\left(x+2\right)-12.
\frac{4x^{4}+11x^{3}-10x^{2}-32x-12}{x+2}
Combine like terms in 4x^{4}+8x^{3}+3x^{3}+6x^{2}-16x^{2}-32x-12.