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\frac{48+7}{12}\left(-\frac{1\times 11+3}{11}\right)-\left(-\frac{1\times 15+1}{15}\right)\left(-\frac{1\times 21+19}{21}\right)\left(-\frac{45}{64}\right)
Multiply 4 and 12 to get 48.
\frac{55}{12}\left(-\frac{1\times 11+3}{11}\right)-\left(-\frac{1\times 15+1}{15}\right)\left(-\frac{1\times 21+19}{21}\right)\left(-\frac{45}{64}\right)
Add 48 and 7 to get 55.
\frac{55}{12}\left(-\frac{11+3}{11}\right)-\left(-\frac{1\times 15+1}{15}\right)\left(-\frac{1\times 21+19}{21}\right)\left(-\frac{45}{64}\right)
Multiply 1 and 11 to get 11.
\frac{55}{12}\left(-\frac{14}{11}\right)-\left(-\frac{1\times 15+1}{15}\right)\left(-\frac{1\times 21+19}{21}\right)\left(-\frac{45}{64}\right)
Add 11 and 3 to get 14.
\frac{55\left(-14\right)}{12\times 11}-\left(-\frac{1\times 15+1}{15}\right)\left(-\frac{1\times 21+19}{21}\right)\left(-\frac{45}{64}\right)
Multiply \frac{55}{12} times -\frac{14}{11} by multiplying numerator times numerator and denominator times denominator.
\frac{-770}{132}-\left(-\frac{1\times 15+1}{15}\right)\left(-\frac{1\times 21+19}{21}\right)\left(-\frac{45}{64}\right)
Do the multiplications in the fraction \frac{55\left(-14\right)}{12\times 11}.
-\frac{35}{6}-\left(-\frac{1\times 15+1}{15}\right)\left(-\frac{1\times 21+19}{21}\right)\left(-\frac{45}{64}\right)
Reduce the fraction \frac{-770}{132} to lowest terms by extracting and canceling out 22.
-\frac{35}{6}-\left(-\frac{15+1}{15}\right)\left(-\frac{1\times 21+19}{21}\right)\left(-\frac{45}{64}\right)
Multiply 1 and 15 to get 15.
-\frac{35}{6}-\left(-\frac{16}{15}\left(-\frac{21+19}{21}\right)\left(-\frac{45}{64}\right)\right)
Add 15 and 1 to get 16.
-\frac{35}{6}-\left(-\frac{16}{15}\left(-\frac{40}{21}\right)\left(-\frac{45}{64}\right)\right)
Add 21 and 19 to get 40.
-\frac{35}{6}-\frac{-16\left(-40\right)}{15\times 21}\left(-\frac{45}{64}\right)
Multiply -\frac{16}{15} times -\frac{40}{21} by multiplying numerator times numerator and denominator times denominator.
-\frac{35}{6}-\frac{640}{315}\left(-\frac{45}{64}\right)
Do the multiplications in the fraction \frac{-16\left(-40\right)}{15\times 21}.
-\frac{35}{6}-\frac{128}{63}\left(-\frac{45}{64}\right)
Reduce the fraction \frac{640}{315} to lowest terms by extracting and canceling out 5.
-\frac{35}{6}-\frac{128\left(-45\right)}{63\times 64}
Multiply \frac{128}{63} times -\frac{45}{64} by multiplying numerator times numerator and denominator times denominator.
-\frac{35}{6}-\frac{-5760}{4032}
Do the multiplications in the fraction \frac{128\left(-45\right)}{63\times 64}.
-\frac{35}{6}-\left(-\frac{10}{7}\right)
Reduce the fraction \frac{-5760}{4032} to lowest terms by extracting and canceling out 576.
-\frac{35}{6}+\frac{10}{7}
The opposite of -\frac{10}{7} is \frac{10}{7}.
-\frac{245}{42}+\frac{60}{42}
Least common multiple of 6 and 7 is 42. Convert -\frac{35}{6} and \frac{10}{7} to fractions with denominator 42.
\frac{-245+60}{42}
Since -\frac{245}{42} and \frac{60}{42} have the same denominator, add them by adding their numerators.
-\frac{185}{42}
Add -245 and 60 to get -185.