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\frac{4^{22}}{\left(4^{5}\right)^{9}}
To multiply powers of the same base, add their exponents. Add 20 and 2 to get 22.
\frac{4^{22}}{4^{45}}
To raise a power to another power, multiply the exponents. Multiply 5 and 9 to get 45.
\frac{1}{4^{23}}
Rewrite 4^{45} as 4^{22}\times 4^{23}. Cancel out 4^{22} in both numerator and denominator.
\frac{1}{70368744177664}
Calculate 4 to the power of 23 and get 70368744177664.