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4^{-12}\times 4^{10}
To raise a power to another power, multiply the exponents. Multiply 5 and 2 to get 10.
4^{-2}
To multiply powers of the same base, add their exponents. Add -12 and 10 to get -2.
\frac{1}{16}
Calculate 4 to the power of -2 and get \frac{1}{16}.