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3\left(x^{6}-25x^{4}-16x^{2}+400\right)
Factor out 3.
x^{4}\left(x^{2}-25\right)-16\left(x^{2}-25\right)
Consider x^{6}-25x^{4}-16x^{2}+400. Do the grouping x^{6}-25x^{4}-16x^{2}+400=\left(x^{6}-25x^{4}\right)+\left(-16x^{2}+400\right), and factor out x^{4} in the first and -16 in the second group.
\left(x^{2}-25\right)\left(x^{4}-16\right)
Factor out common term x^{2}-25 by using distributive property.
\left(x-5\right)\left(x+5\right)
Consider x^{2}-25. Rewrite x^{2}-25 as x^{2}-5^{2}. The difference of squares can be factored using the rule: a^{2}-b^{2}=\left(a-b\right)\left(a+b\right).
\left(x^{2}-4\right)\left(x^{2}+4\right)
Consider x^{4}-16. Rewrite x^{4}-16 as \left(x^{2}\right)^{2}-4^{2}. The difference of squares can be factored using the rule: a^{2}-b^{2}=\left(a-b\right)\left(a+b\right).
\left(x-2\right)\left(x+2\right)
Consider x^{2}-4. Rewrite x^{2}-4 as x^{2}-2^{2}. The difference of squares can be factored using the rule: a^{2}-b^{2}=\left(a-b\right)\left(a+b\right).
3\left(x-5\right)\left(x+5\right)\left(x-2\right)\left(x+2\right)\left(x^{2}+4\right)
Rewrite the complete factored expression. Polynomial x^{2}+4 is not factored since it does not have any rational roots.