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Differentiate w.r.t. x
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6\times 3x^{6-1}+3\left(-16\right)x^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
18x^{6-1}+3\left(-16\right)x^{3-1}
Multiply 6 times 3.
18x^{5}+3\left(-16\right)x^{3-1}
Subtract 1 from 6.
18x^{5}-48x^{3-1}
Multiply 3 times -16.
18x^{5}-48x^{2}
Subtract 1 from 3.