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250-\left(10-\left(3-1\right)+2\right)+216-\left(8+3-\left(12-10\right)\right)
Add 6 and 4 to get 10.
250-\left(10-2+2\right)+216-\left(8+3-\left(12-10\right)\right)
Subtract 1 from 3 to get 2.
250-\left(8+2\right)+216-\left(8+3-\left(12-10\right)\right)
Subtract 2 from 10 to get 8.
250-10+216-\left(8+3-\left(12-10\right)\right)
Add 8 and 2 to get 10.
240+216-\left(8+3-\left(12-10\right)\right)
Subtract 10 from 250 to get 240.
456-\left(8+3-\left(12-10\right)\right)
Add 240 and 216 to get 456.
456-\left(11-\left(12-10\right)\right)
Add 8 and 3 to get 11.
456-\left(11-2\right)
Subtract 10 from 12 to get 2.
456-9
Subtract 2 from 11 to get 9.
447
Subtract 9 from 456 to get 447.