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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(-4x^{5})
Multiply 2 and -2 to get -4.
5\left(-4\right)x^{5-1}
The derivative of ax^{n} is nax^{n-1}.
-20x^{5-1}
Multiply 5 times -4.
-20x^{4}
Subtract 1 from 5.
-4x^{5}
Multiply 2 and -2 to get -4.