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Differentiate w.r.t. x
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\frac{5}{4}\times 2x^{\frac{5}{4}-1}+\frac{1}{4}\times 6x^{\frac{1}{4}-1}-4\times 3x^{-4-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{5}{2}x^{\frac{5}{4}-1}+\frac{1}{4}\times 6x^{\frac{1}{4}-1}-4\times 3x^{-4-1}
Multiply \frac{5}{4} times 2.
\frac{5}{2}\sqrt[4]{x}+\frac{1}{4}\times 6x^{\frac{1}{4}-1}-4\times 3x^{-4-1}
Subtract 1 from \frac{5}{4}.
\frac{5}{2}\sqrt[4]{x}+\frac{3}{2}x^{\frac{1}{4}-1}-4\times 3x^{-4-1}
Multiply \frac{1}{4} times 6.
\frac{5}{2}\sqrt[4]{x}+\frac{3}{2}x^{-\frac{3}{4}}-4\times 3x^{-4-1}
Subtract 1 from \frac{1}{4}.
\frac{5}{2}\sqrt[4]{x}+\frac{3}{2}x^{-\frac{3}{4}}-12x^{-4-1}
Multiply \frac{1}{4} times 6.
\frac{5}{2}\sqrt[4]{x}+\frac{3}{2}x^{-\frac{3}{4}}-12x^{-5}
Subtract 1 from -4.