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2\times 3\times 4^{10}\times 6^{-3}
To multiply powers of the same base, add their exponents. Add 5 and 5 to get 10.
6\times 4^{10}\times 6^{-3}
Multiply 2 and 3 to get 6.
6\times 1048576\times 6^{-3}
Calculate 4 to the power of 10 and get 1048576.
6291456\times 6^{-3}
Multiply 6 and 1048576 to get 6291456.
6291456\times \frac{1}{216}
Calculate 6 to the power of -3 and get \frac{1}{216}.
\frac{262144}{9}
Multiply 6291456 and \frac{1}{216} to get \frac{262144}{9}.