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16\left(x^{2}-4xy+4y^{2}\right)-9\left(x+y\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(x-2y\right)^{2}.
16x^{2}-64xy+64y^{2}-9\left(x+y\right)^{2}
Use the distributive property to multiply 16 by x^{2}-4xy+4y^{2}.
16x^{2}-64xy+64y^{2}-9\left(x^{2}+2xy+y^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(x+y\right)^{2}.
16x^{2}-64xy+64y^{2}-9x^{2}-18xy-9y^{2}
Use the distributive property to multiply -9 by x^{2}+2xy+y^{2}.
7x^{2}-64xy+64y^{2}-18xy-9y^{2}
Combine 16x^{2} and -9x^{2} to get 7x^{2}.
7x^{2}-82xy+64y^{2}-9y^{2}
Combine -64xy and -18xy to get -82xy.
7x^{2}-82xy+55y^{2}
Combine 64y^{2} and -9y^{2} to get 55y^{2}.
16\left(x^{2}-4xy+4y^{2}\right)-9\left(x+y\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(x-2y\right)^{2}.
16x^{2}-64xy+64y^{2}-9\left(x+y\right)^{2}
Use the distributive property to multiply 16 by x^{2}-4xy+4y^{2}.
16x^{2}-64xy+64y^{2}-9\left(x^{2}+2xy+y^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(x+y\right)^{2}.
16x^{2}-64xy+64y^{2}-9x^{2}-18xy-9y^{2}
Use the distributive property to multiply -9 by x^{2}+2xy+y^{2}.
7x^{2}-64xy+64y^{2}-18xy-9y^{2}
Combine 16x^{2} and -9x^{2} to get 7x^{2}.
7x^{2}-82xy+64y^{2}-9y^{2}
Combine -64xy and -18xy to get -82xy.
7x^{2}-82xy+55y^{2}
Combine 64y^{2} and -9y^{2} to get 55y^{2}.