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16\left(\left(m^{2}\right)^{2}-8m^{2}+16\right)-4\times \left(3n\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(m^{2}-4\right)^{2}.
16\left(m^{4}-8m^{2}+16\right)-4\times \left(3n\right)^{2}
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
16m^{4}-128m^{2}+256-4\times \left(3n\right)^{2}
Use the distributive property to multiply 16 by m^{4}-8m^{2}+16.
16m^{4}-128m^{2}+256-4\times 3^{2}n^{2}
Expand \left(3n\right)^{2}.
16m^{4}-128m^{2}+256-4\times 9n^{2}
Calculate 3 to the power of 2 and get 9.
16m^{4}-128m^{2}+256-36n^{2}
Multiply 4 and 9 to get 36.
16\left(\left(m^{2}\right)^{2}-8m^{2}+16\right)-4\times \left(3n\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(m^{2}-4\right)^{2}.
16\left(m^{4}-8m^{2}+16\right)-4\times \left(3n\right)^{2}
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
16m^{4}-128m^{2}+256-4\times \left(3n\right)^{2}
Use the distributive property to multiply 16 by m^{4}-8m^{2}+16.
16m^{4}-128m^{2}+256-4\times 3^{2}n^{2}
Expand \left(3n\right)^{2}.
16m^{4}-128m^{2}+256-4\times 9n^{2}
Calculate 3 to the power of 2 and get 9.
16m^{4}-128m^{2}+256-36n^{2}
Multiply 4 and 9 to get 36.