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16\left(-x^{2}+4x+25\right)
Calculate 5 to the power of 2 and get 25.
16\left(-x^{2}\right)+64x+400
Use the distributive property to multiply 16 by -x^{2}+4x+25.
-16x^{2}+64x+400
Multiply 16 and -1 to get -16.
16\left(-x^{2}+4x+25\right)
Calculate 5 to the power of 2 and get 25.
16\left(-x^{2}\right)+64x+400
Use the distributive property to multiply 16 by -x^{2}+4x+25.
-16x^{2}+64x+400
Multiply 16 and -1 to get -16.